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Additionally, we find that the decrease in glutamate brought by acivicin could be rescued by administration of pyroglutamate (5-oxoproline), a downstream metabolite in the glutathione pathway that is a precursor of glutamate (Fig
doi: 10.3389/fneur.2022.844697 27
Conclusion As of now, there is a lack of robust evidence in favour of glutathione for the treatment of hyperpigmentation
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